CORLUTNA: CORrole based systems for LUminescent Thermometry at Nanoscale

Project funded by Fundação para a Ciência e a Tecnologia, I.P. (FCT) (Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Ci), grant PTDC/QUI-QOR/31523/2017. Funded amount: EUR 35,707.20, as stated by the source. Runs 2018-07-26 to 2022-07-25. Keywords: Corrole, Quantum dot, Luminescence, nanothermometer, Exact sciences. Source: OpenAIRE Graph, from the funder's project data (collected by OpenAIRE on 2025-07-19); national funding data, not CORDIS; selected because its keywords name quantum. Abstract given by the source: Temperature (T) is a fundamental parameter that affects the behavior of physical, chemical and biological systems in a wide variety of ways. Measuring T is important in many fields: photonic devices, nano/microelectronics, medical diagnostics, nanomedicine. The design of biocompatible temperature nanosensors to measure T in cells and tissues with sufficient accuracy is a challenge. Measuring T will able to monitor and discern subtle T alterations within the cell and to relate them to early detection of disease. One possible approach is to use dye luminescence thermometers. In this sense corroles have remarkable chemical and photophysical properties such fluorescence, phosphorescence and delay thermal fluorescence suitable to be used as dyes. Additionally, the combination of two emitting entities as QDs, in ratiometric thermometers can overcome some drawbacks of mono-emitting sensor. The combination of properties of corroles and quantum dots foresee the preparation of corrole decorated nanocrystals and further encapsulation on bioplymers, as an innovator class of biocompatible ratiometric thermometers with intrinsic dual emitters to be use at nanoscale. This project aims to prepare these systems , evaluate their luminescence properties and their temperature dependence and perform an evaluation of their cytotoxicity in cells. The synthesis of polyhalogenated trans-A2B metallocorroles will be considered with proper substituents to be successful anchored to the surface of nanocrystals such CdSe/ZnS and ZnSe:Mn/ZnS. The preparation of nanocrystals decorated with corroles will be carried out by self-assembly reactions and their encapsulation in selected polysaccharides will be developed. A full structural and luminescence characterization of the hybrids will be performed and the local temperature of corrole-based luminescent thermometers will be accessed based on the relative intensities of the emissions of nanocrystals and corroles. A cytotoxicity evaluation of the [shortened; the full text is on the OpenAIRE page]

Original source.

Source: OpenAIRE Graph: projects of national funders, OpenAIRE, from the project data of Fundação para a Ciência e a Tecnologia, I.P. (FCT). Retrieved 2026-10-28. Licence: Creative Commons Attribution 4.0 (OpenAIRE Graph). Selected metadata, adapted presentation; the publisher's record is authoritative. No endorsement by the source is implied. Licence: Creative Commons Attribution 4.0 (CC BY 4.0).

AI-assisted summary: The CORLUTNA project, funded by FCT with a grant of EUR 35,707.20, focuses on developing biocompatible nanosensors for temperature measurement in cells and tissues. It runs from July 26, 2018, to July 25, 2022, and involves keywords like Corrole and Quantum dot. Suggested technology pillar: sensing. Generated by AI from the public source text; it may contain errors and the original source is authoritative.