Development and testing of an analytical system for simultaneous detection of cancer biomarkers

Operation co-funded by EU cohesion policy (European Social Fund (ESF)) under the programme EU Structural Funds Investments - LT - ERDF/ESF/CF/YEI (2014LT16MAOP001), managing authority: Finansų ministerija. The source names no beneficiary for this operation. Location: Vilnius County (NUTS LT011); Lithuania. Budget: total eligible expenditure EUR 85,008.28; EU co-financing EUR 85,008.28 (co-financing rate 100%), as stated by the source. Runs 2020-09-01 to 2022-08-31. Source: Kohesio, EU cohesion policy projects managed by national and regional authorities (not CORDIS); selected because its summary names quantum technology. Summary from Kohesio (English machine translation by the source): According to the data of the National Cancer Institute, about 15000 oncological diseases are diagnosed in Lithuania each year. Thus, new analytical systems for the early detection of cancer are an important modern task. The project focuses on the development of a model optical analytic system that allows the simultaneous detection of multiple cancer biomarkers and its performance testing. Quantum dots will be adapted to multi-color imaging of cancer biomarkers. This variant of the analysis allows the analysis to be carried out from a single small volume sample, and the simultaneous detection of biomarkers is more reliable and allows monitoring of the process of cancer development. Fluorescence spectroscopy will be used to monitor the glow of quantum dots. The planned application of magnetic particles at the biomarker collection/concentration stage will facilitate the necessary washing stages and reduce sample and material volumes. Surface plasma resonance spectroscopy, which is characterised by high sensitivity and reliability in biomolecule interactions, will be used to test the effectiveness of antibody conjugation of quantum points and magnetic particles on the surface and in interaction studies with the analyte. During the implementation of the project, the optimal conditions for the preparation of the analytical system will be selected. The studies are planned to be carried out using random and targeted antibody immobilisation strategies. Selecting the format for determining the analyte concentration (direct, indirect substitution and/or layered, and/or competitive inhibition) will improve the analytical performance of the model biomarker detection system. The model analysis system for cancer biomarkers developed in the project is possibly adapted for the detection of other biomarkers. The implementation of this project will allow the trainee not only to develop scientific excellence in areas close to him, but also to gain experience in new areas.

Original source.

Source: Kohesio (EU cohesion policy projects), European Commission, Directorate-General for Regional and Urban Policy (DG REGIO). Retrieved 2026-10-21. Licence: CC0 1.0 (Cohesion Open Data Platform, dataset 2014-2020 Kohesio projects). Selected metadata, adapted presentation; the publisher's record is authoritative. No endorsement by the source is implied. Licence: public domain dedication (CC0 1.0).

AI-assisted summary: The project, co-funded by the EU, aims to develop an optical analytical system for simultaneous detection of cancer biomarkers in Vilnius County, Lithuania, with a budget of EUR 85,008.28. It runs from September 2020 to August 2022 and utilizes quantum dots for multi-color imaging. Suggested technology pillar: sensing. Generated by AI from the public source text; it may contain errors and the original source is authoritative.