Pulsed DNP and EPR spectroscopy for biological applications – the next breakthrough in magnetic resonance

Project funded by Novo Nordisk Foundation (Investigators), grant NNF22OC0076002. Participating organisations named by the source: Aarhus University. Runs n/a to 2027-12-31. Keywords: Biological Physics, Methods, Nanotechnology, Physical Chemistry/Chemical Physics, Quantum Technologies. Source: OpenAIRE Graph, from the funder's project data (collected by OpenAIRE on 2025-08-01); national funding data, not CORDIS; selected because its keywords name quantum. Abstract given by the source: Combining frontline pulsed microwave technology and advanced spin engineering we will drive the next breakthrough of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) as prime analytical tools in structural biology. Along with X-ray diffraction and cryo-EM, NMR is a key source to atomic-resolution information about molecular structure and dynamics without the need for crystalline or 2D ordered samples. A fundamental drawback of NMR is low sensitivity, which can be solved by dynamic nuclear polarization (DNP) enhancement transferring orders of magnitude larger polarization from electrons to nuclei. Developing advanced multiple dimensional pulse methods we will transform DNP and EPR in a fashion resembling the transformation seen for pulsed NMR in the past decades, however, with much higher sensitivity. This opens fantastic new opportunities in structural biology, here to be demonstrated for membrane proteins, amyloid fibrils, and photo receptors._x000D_ _x000D_

Original source.

Source: OpenAIRE Graph: projects of national funders, OpenAIRE, from the project data of Novo Nordisk Foundation. Retrieved 2026-11-02. Licence: Creative Commons Attribution 4.0 (OpenAIRE Graph). Selected metadata, adapted presentation; the publisher's record is authoritative. No endorsement by the source is implied. Licence: Creative Commons Attribution 4.0 (CC BY 4.0).

AI-assisted summary: Project funded by Novo Nordisk Foundation, running until 2027, aims to advance NMR and EPR techniques for structural biology using pulsed microwave technology and spin engineering. Participating organisation: Aarhus University. Suggested technology pillar: sensing. Generated by AI from the public source text; it may contain errors and the original source is authoritative.