THE REGULATION OF QUANTUM RELEASE OF NEUROTRANSMITTERS IN THE CHROMAFIN CELL BY VESICULAR FACTORS.

Operation co-funded by EU cohesion policy (European Regional Development Fund (ERDF)) under the programme Multi-regional Spain - ERDF (2014ES16RFOP002), managing authority: Subdirección General de Gestión del FEDER, de la Dirección General de Fondos Europeos del Ministerio de Hacienda.. The source names no beneficiary for this operation. Location: Tenerife (NUTS ES709); Spain. Budget: total eligible expenditure EUR 260,150; EU co-financing EUR 221,127.5 (co-financing rate 85%), as stated by the source. Runs 2014-01-01 to 2017-12-31. Source: Kohesio, EU cohesion policy projects managed by national and regional authorities (not CORDIS); selected because its title uses a quantum word. Summary from Kohesio (English machine translation by the source): THE CHROMAFINE CELLS OF THE ADRENAL MARROW ARE THE MOST USED MODEL TO STUDY THE MECHANISMS THAT UNDERLIE NEUROSECTION. THESE CELLS STORE IN THEIR SECRETIVE VESICULAS ALTISIMAS CONCENTRATIONS OF CATECHOLAMINES AND OTHER SOLUTES, WHICH WILL BE RELEASED BY EXOCYTOSIS. OVER THE LAST YEARS IN OUR LABORATORY WE HAVE BEEN CHARACTERISING THE ROLE OF THE MAIN INTRAVESICULAR COMPONENTS (CHROMOGRANINS, H+ AND CA2+) IN THE STORAGE OF CATECHOLAMINES AND THEIR EXOCYTOSIS. SIMILARLY, SEVERAL GROUPS, INCLUDING OURS, HAVE SHOWN THAT THE VESICULAR ACCUMULATION OF EXOGENOUS SUBSTANCES (FALSE TRANSMITTERS) IS BEHIND MUCH OF THE THERAPEUTIC EFFECTS OF SOME ANTIHYPERTENSIVE, ANTIEPILEPTIC AND ANTIDEPRESSANT DRUGS. RECENTLY, WE HAVE BEGUN TO STUDY THE QUANTITATIVELY SECOND LARGEST VESICULAR COMPONENT, THE ATP THAT IS SURPRISINGLY PRESENT IN ALL THE SECRETIVE VESICLES OF ALL KNOWN LIVING BEINGS. with THE DEVELOPMENT OF THIS PROJECT WE WE WE PLANTED: A) EVALUATE THE ROLE OF ATP AS A NEGATIVE OSMOTIC AGENT, FACILITATING THE AGGREGATION OF VESICULAR CATECHOLAMINES. B) COMPLETE THE STUDY OF INTERACTIONS BETWEEN QUANTITATIVELY IMPORTANT COMPONENTS OF INTRAVESICULAR COCKTAIL: CATECHOLAMINES, ATP, CALCIUM, CHROMOGRANINS AND PH. C) CHARACTERISE AND MEASURE THE CYTOOSOLICAL DISTRIBUTION OF ATP IN BASAL CONDITIONS AND AGAINST SECRETIVE STIMULI. To assess the potential impact of the ATP in the storage of CATECOLAMINs, in the movement of the VESICULES and in their exocitesis and (e) to try to verify the hypothesis of the FUNCTIONAL RESERVORATION OF VESICULES that are not freed before SECRETAGOGY STIMULS. the DATE OF ALL STUDIES IN CROMAFINE CELLS have been developed with MYXTA ADRENERGIC and NORADRENERGIC POULATIONS. We now have a PNMT-KO RATON CEPA that dear to ADRENALINE, it will allow us to buy the INTERACTIONS BETWEEN NORADRENALINE AND INTRAVESICULARES COMPONENTS. we will use DIVERSAS approaches IN CROMAFINE CELLS, PC12, ARTIFICIAL CELLS AND EXPERIMENTS IN VITRO. WE WILL USE EXPERIMENTAL [shortened; the full text is on the Kohesio page]

Original source.

Source: Kohesio (EU cohesion policy projects), European Commission, Directorate-General for Regional and Urban Policy (DG REGIO). Retrieved 2026-10-21. Licence: CC0 1.0 (Cohesion Open Data Platform, dataset 2014-2020 Kohesio projects). Selected metadata, adapted presentation; the publisher's record is authoritative. No endorsement by the source is implied. Licence: public domain dedication (CC0 1.0).

AI-assisted summary: The operation focuses on the regulation of neurotransmitter release in chromaffin cells, co-funded by the EU with a budget of EUR 260,150. It ran from January 1, 2014, to December 31, 2017, in Tenerife, Spain. Suggested technology pillar: enabling. Generated by AI from the public source text; it may contain errors and the original source is authoritative.