SpaceInt: Spatially controlled structuring of quantum boxes for dynamic study of integrins

Operation co-funded by EU cohesion policy (European Regional Development Fund (ERDF)) under the programme Champagne-Ardenne - ERDF/ESF/YEI (2014FR16M0OP004), managing authority: Conseil régional Grand Est. The source names no beneficiary for this operation. Location: Aube (NUTS FRF22); France. Budget: total eligible expenditure EUR 106,950; EU co-financing EUR 53,475 (co-financing rate 50%), as stated by the source. Runs 2019-10-01 to 2022-12-31. Source: Kohesio, EU cohesion policy projects managed by national and regional authorities (not CORDIS). Summary from Kohesio (English machine translation by the source): Adhesion and cell migration are important processes that play a critical role in the different stages of cancer development (proliferation, angiogenesis, metastasis...). To adhere and move the cell will have to establish strong physicochemical links with its environment. The latter consists of an extremely complex extracellular matrix, resulting from the arrangement of different proteins (collagen, fibronectin...), on which the cells move. The anchorage between a cell and this matrix is mainly controlled by a membrane receptor family, the integrins, which relay different signaling pathways regulating adhesion and migration. In many cancers, we see an increase in the expression of integrins that promotes tumor invasion but also resistance to therapies. Integrins therefore offer a fundamental therapeutic target for the treatment of cancers. The aim of this project is to explore the possibilities offered by a fluorescence nanoscopy technique developed in the L2n laboratory to study the spatio-temporal dynamics of integrins at the nanoscale (on living cells). This technique is based on the FRET (Förster Resonance Energy Transfer) via the activation of a glass surface by quantum boxes (QDs).

Original source.

Source: Kohesio (EU cohesion policy projects), European Commission, Directorate-General for Regional and Urban Policy (DG REGIO). Retrieved 2026-10-21. Licence: CC0 1.0 (Cohesion Open Data Platform, dataset 2014-2020 Kohesio projects). Selected metadata, adapted presentation; the publisher's record is authoritative. No endorsement by the source is implied. Licence: public domain dedication (CC0 1.0).

AI-assisted summary: The project "SpaceInt" focuses on the spatial control of quantum boxes to study integrins, crucial for cell adhesion and migration in cancer development. It is co-funded by the EU with a budget of EUR 106,950, running from October 2019 to December 2022 in Aube, France. Suggested technology pillar: sensing. Generated by AI from the public source text; it may contain errors and the original source is authoritative.